GS-441524

Thousands of cats worldwide suffer from the debilitating condition known as feline infectious peritonitis (FIP). Historically, FIP has been fatal in almost all cases. However, in recent years, with the help of committed researchers, GS-441524, has demonstrated encouraging outcomes in treating FIP. Studies have shown a 92% success rate in treating the disease by administering GS-441524 according to a specific protocol. 

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GS-441524 offers hope and a potential breakthrough for FIP

improvement is often seen within a few days

By preventing viral multiplication, GS-441524 lowers the viral burden and makes it possible for the cat's immune system

Since the 1960s, Niels C. Pedersen, who is currently an emeritus professor at the UC Davis School of Veterinary Medicine, has been researching FIP. He experimented with GS-441524, in 2018 and 2019 as a possible cure. The remarkable results of Pedersen’s work were recently covered by The Atlantic: In a field study, GS-441524 effectively treated naturally occurring FIP in 25 out of 31 cats—“an unheard-of recovery rate.”

About MedicaPharma

MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.

What is GS-441524

GS-441524, created by the pharmaceutical business Gilead Sciences, prevents viruses from replicating. Remdesivir was also developed by Gilead developed, almost identical to the first, by altering a single atom to increase the molecule's capacity to enter human cells.

Why Choose MedicaPharma

We are committed to supplying high-quality GMP products with logistics according to GDP regulations.

Table of Contents

Mechanism of Action

When GS-441524 is intracellularly triple-phosphorylated, its active analogue, 1′-cyano-substituted adenosine triphosphate, is produced. This analogue competes with endogenous NTPs to be incorporated into nascent viral RNA transcripts and causes delayed chain termination of RNA-dependent RNA polymerase. This directly disrupts viral RNA replication.[4]

Benefits and Advantages

FIP had no known cure until recently, but GS-441524, an antiviral drug, is now available and works well to treat the illness. Numerous nations offer GS-441524, which has been shown to be both safe and effective.

The current guidelines suggest treating cats for 12 weeks in order to fully remove the illness and maximise their chances of recovery. As therapies progress, shorter courses might be suggested in the future. Antiviral medicine dosages vary depending on the kind of FIP; cats with neurological and/or ocular FIP are typically prescribed greater dosages.

GS-441524 has remarkably few systemic side effects.

Side Effects and Risks

It’s crucial to remember that different cats react differentl, and that results can differ from person to person. It is essential to conduct ongoing assessments of the cat’s condition, close observation, and routine veterinarian check-ups in order to determine the efficacy and make any required modifications.

The typical course lasts 12 weeks, although some cats—typically younger ones with wet FIP—can be healed in as short as 8 weeks, if not sooner. It’s possible that certain cats will even need lengthier times and dose modifications. In cats destined for cures, critical blood parameters including haematocrit, total protein, albumin and globulin levels, and absolute lymphocyte counts typically return to normal around 8–10 weeks, at which point there is frequently an unexpected rise in activity levels. The cat’s own immunity to the illness is thought to develop between 8 and 10 weeks in, though this is not confirmed. 

Pain at the injection sites is the main side effect of GS, and it varies from cat to cat and depending on how skilled the person administering the with injections (typically the owner). Some owners have injection site sores, which mainly happen when the injection site is not moved about the body (avoid the area between the shoulders) or administered into the layers of muscle and nerve beneath the subcutis. I advise choosing locations that are one inch below the shoulder blades, one third to half of the way down the chest and abdomen, and down the back to 1-2 inches before the tailhead. Before receiving an injection, gabapentin is frequently used to reduce pain.

In certain cats, it may result in mild kidney damage; however, overt renal illness does not develop from this. 

Our GS-441524 is produced in a GMP facility. Several veterinary institutes in Europe use our raw materials with excellent results. References are available upon request.

GS-441524 FAQ

GS-441524, created by the pharmaceutical business Gilead Sciences, prevents viruses from replicating. Remdesivir was another medication that Gilead developed, almost identical to the first, by altering a single atom to increase the molecule’s capacity to enter human cells.

MedicaPharma, a supplier based in the European Union, offers GMP products with GDP-compliant logistics to hospitals, pharmacies, commercial (compounding) pharmacies, research institutes, and universities. For inquiries or to request a quote, please click here.

When choosing a pharmaceutical supplier, it’s vital to prioritize reliability, ensuring consistent and timely delivery of high-quality products. Additionally, expertise and compliance with regulatory standards are essential to guarantee the safety and efficacy of pharmaceutical supplies.
EU-based supplier MedicaPharma provides high-quality GMP products with logistics according to GDP regulations to leading sales, research, and education institutions. Click here to request a quote.